BCL-10[20003]

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Western blot analysis using BCL10 mouse mAb against NIH/3T3 (1), Hela (2), MCF-7 (3) and Jurkat (4) cell lysate.

Confocal Immunofluorescence analysis of Hela cells using BCL10 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Flow cytometric analysis of Hela cells using BCL10 mouse mAb (green) and negative control (purple).

Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10 mouse mAb with DAB staining.

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Mouse Monoclonal Antibody to BCL-10

货号：
20003
别名：
CLAP; Me10; CIPER; c-E10; CARMEN
应用：
WB,IHC,ICC,FCM
反应种属：
Human,Mouse
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to BCL-10

Description
Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Description

Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important
role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other
CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as
upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which
encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to
synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to
the same pathogenetic process that leads to the malignancy.

References
1. Willis, T.G., et al. (1999) Cell. 96, 35-45. 2. Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019. 3. Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409

Specification
Aliases	CLAP; Me10; CIPER; c-E10; CARMEN
Entrez GeneID	8915
Swissprot	O95999
clone	4F8
WB Predicted band size	26kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Purified recombinant fragment of human BCL-10 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.