Description

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

References
Phytother Res. 2012 Nov;26(11):1688-94. Biochim Biophys Acta. 2011 Jun;1811(6):397-408.

Specification
Aliases	FH; FHC; LDLCQ2
Entrez GeneID	3949
Swissprot	P01130
clone	7H5B11
WB Predicted band size	95.4kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
FCM	1/200 - 1/400
ELISA	1/10000