Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

References
1.J Virol. 2015 Nov;89(22):11396-405. 2.Immunogenetics. 2014 Dec;66(12):675-81.

Specification
Aliases	CD289
Entrez GeneID	54106
Swissprot	Q9NR96
clone	6B2G1
WB Predicted band size	115.8kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human TLR9 (AA: 868-1016) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
FCM	1/200 - 1/400
ELISA	1/10000