Description

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

References
1.PLoS One. 2015 Dec 23;10(12):e0145269. 2.Iran J Allergy Asthma Immunol. 2014 Feb;13(1):33-9.

Specification
Aliases	HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R
Entrez GeneID	3359
Swissprot	P46098
clone	3B11C10
WB Predicted band size	55.3kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human HTR3A (AA: extra 24-157) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
IHC	1/200 - 1/1000
ICC	1/100 - 1/500
FCM	1/200 - 1/400
ELISA	1/10000