Description

NCOA3: nuclear receptor coactivator 3. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

References
1. Mol Cell Biol. 2005 Sep;25(18):8273-84. 2. J Clin Oncol. 2006 Oct 1;24(28):4565-9.

Specification
Aliases	ACTR; AIB1
Entrez GeneID	8202
Swissprot	Q9Y6Q9
clone	2C11B12
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of NCOA3 (aa1-200) expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ELISA	1/10000