Description

MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.

References
1. Int J Oncol. 2002 Jul;21(1):197-205. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Nat Genet. 2004 Jan;36(1):40-5.

Specification
Aliases	CHK; CTK
Entrez GeneID	4145
Swissprot	P42679
clone	9D7
WB Predicted band size	56kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human MATK expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
FCM	1/200 - 1/400
ELISA	1/10000