MAP2K7[30291]

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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Immunofluorescence analysis of Hela cells using MAP2K7 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of Hela cells using MAP2K7 mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using MAP2K7 mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human muscle tissues using MAP2K7 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to MAP2K7

货号：
30291
别名：
MKK7; Jnkk2; MAPKK7; PRKMK7
应用：
IHC,ICC,FCM
反应种属：
Human
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to MAP2K7

Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

References
1. Biochem J. 2010 Mar 29;427(2):237-45. 2. J Immunol. 2008 Sep 1;181(5):3252-8.

Specification
Aliases	MKK7; Jnkk2; MAPKK7; PRKMK7
Entrez GeneID	5609
Swissprot	O14733
clone	4E5
WB Predicted band size	48kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human MAP2K7 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.