MCAM[30505]

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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Western blot analysis using MCAM mouse mAb against HUVE-12 (1), EVC-304 (2), HELA (3) and MCF-7 (4) cell lysate.

Flow cytometric analysis of MCF-7 cells using MCAM mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using MCAM mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using MCAM mouse mAb with DAB staining.

Mouse Monoclonal Antibody to MCAM

货号：
30505
别名：
CD146; MUC18
应用：
WB,IHC,FCM
反应种属：
Human
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to MCAM

Description
The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Description

The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

References
1. Cancer Lett. 2013 Apr 28;330(2):150-62. 2. J Biol Chem. 2013 Jan 25;288(4):2571-9.

Specification
Aliases	CD146; MUC18
Entrez GeneID	4162
Swissprot	P43121
clone	6C3E6
WB Predicted band size	71.6kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide