Description

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.

References
1.Cancer Lett. 2016 Apr 28;374(1):127-35. 2.Oncol Rep. 2014 Nov;32(5):2031-7.

Specification
Aliases	ALDA; GSD12; HEL-S-87p
Entrez GeneID	226
Swissprot	P04075
clone	2H2B1
WB Predicted band size	39.4kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human ALDOA (AA: 9-145) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
ICC	1/100 - 1/500
FCM	1/200 - 1/400
ELISA	1/10000