Description

This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

References
1.Hum Mol Genet. 2013 Mar 1;22(5):927-40. 2.Clin Genet. 2012 May;81(5):479-84.

Specification
Aliases	HKPX2
Entrez GeneID	2743
Swissprot	P48167
clone	3B8A8
WB Predicted band size	56.1kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human GLRB (AA: extra 23-160) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
ICC	1/200 - 1/1000
FCM	1/200 - 1/400
ELISA	1/10000