Description

AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

References
1. Cancer Res. 2006 Nov 15;66(22):11077-83. 2. Mol Cell Biol. 2007 Oct;27(20):7125-42.

Specification
Aliases	KD; AIS; TFM; DHTR; SBMA
Entrez GeneID	367
Swissprot	P10275
clone	1A9D12
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of AR (aa689-919) expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ELISA	1/10000