Description

Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

References
1. Blood. 2007 Dec 1;110(12):4086-95. 2. Clin Exp Immunol. 2006 Jul;145(1):63-70.

Specification
Aliases	PRTN3; ACPA; CANCA
Entrez GeneID	5657
Swissprot	P24158
clone	3B4
WB Predicted band size	28kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ELISA	1/10000