PTEN[20399]

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Western blot analysis using PTEN mouse mAb against Hela (1) and NIH/3T3 (2) cell lysate.

Confocal Immunofluorescence analysis of Hela (left) and HepG2 (right) cells using PTEN mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Flow cytometric analysis of Hela cells using PTEN mouse mAb (right) and negative control (left).

Mouse Monoclonal Antibody to PTEN

货号：
20399
别名：
BZS; MHAM; TEP1; PTEN1
应用：
WB,ICC,FCM
反应种属：
Human,Mouse
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to PTEN

Description
PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Description

PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

References
1. Nat Genet. 1998 Aug;19(4):348-55. 2. Oncogene. 1999 May 20;18(20):3181-5. 3. Eur J Immunol. 2002 Apr;32(4):1196-204.

Specification
Aliases	BZS; MHAM; TEP1; PTEN1
Entrez GeneID	5728
Swissprot	P60484
clone	1B8
WB Predicted band size	54kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Purified recombinant fragment of PTEN expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.