Description

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

References
1. J Invest Dermatol. 1992 Dec;99(6):734-42. 2. Nature. 1997 Aug 7;388(6642):548-54. 3. Exp Neurol. 2002 Nov;178(1):104-11. 4. Science. 2004 May 7;304(5672):870-5.

Specification
Aliases	CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR
Entrez GeneID	4804
Swissprot	P08138
clone	2F1C2
WB Predicted band size	45kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human NGFR expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ICC	1/200 - 1/1000
FCM	1/200 - 1/400
ELISA	1/10000