Description

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References
1. EMBO J. 2007 Mar 21;26(6):1511-21. 2. J Biol Chem. 2007 Jun 15;282(24):17806-15. 3. Mol Cell. 2007 Jul 20;27(2):262-74.

Specification
Aliases	PP-1A; PPP1A; MGC1674; MGC15877; PP1alpha; PPP1CA
Entrez GeneID	5499
Swissprot	P62136
clone	6D1
WB Predicted band size	38kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Purified recombinant fragment of human PPP1A expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
ELISA	1/10000