Description

Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

References
1. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E8-E15. 2. Oncol Rep. 2004 Jan;11(1):25-32. 3. Cancer Res. 2003 Jan 1;63(1):196-206.

Specification
Aliases	PKBB; PRKBB; PKBBETA; RAC-BETA
Entrez GeneID	208
Swissprot	P31751
clone	1B6
WB Predicted band size	60kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat,Monkey
Immunogen	Purified recombinant fragment of human AKT2 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
IHC	1/200 - 1/1000
ICC	1/200 - 1/1000
ELISA	1/10000