GPNMB[30520]

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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Western blot analysis using GPNMB mouse mAb against PANC1 (1) and PC-3 (2) cell lysate.

Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using GPNMB mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissues using GPNMB mouse mAb with DAB staining.

Mouse Monoclonal Antibody to GPNMB

货号：
30520
别名：
NMB; HGFIN
应用：
WB,IHC
反应种属：
Human
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to GPNMB

Description
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Description

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

References
1. Prostate. 2012 Sep 15;72(13):1431-42. 2. Melanoma Res. 2010 Jun;20(3):184-90.

Specification
Aliases	NMB; HGFIN
Entrez GeneID	10457
Swissprot	Q14956
clone	7C10E5
WB Predicted band size	64kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human GPNMB (AA: 31-260) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide