Description

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

References
Clin Biochem. 2013 Dec;46(18):1808-11. Cancer Lett. 2012 Oct 28;323(2):208-14.

Specification
Aliases	CPSD; CLN10; HEL-S-130P
Entrez GeneID	1509
Swissprot	P07339
clone	2H4H5
WB Predicted band size	44.6kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CTSD (AA: 1-100) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
IHC	1/200 - 1/1000
ELISA	1/10000