Description

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

References
1.Med Sci Monit. 2016 Nov 1;22:4139-4145. 2.Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2259-64.

Specification
Aliases	BCLW; BCL-W; PPP1R51; BCL2-L-2
Entrez GeneID	599
Swissprot	Q92843
clone	4G12E6
WB Predicted band size	20.7kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human BCL2L2 (AA: 6-118) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
IHC	1/200 - 1/1000
ICC	1/200 - 1/1000
FCM	1/200 - 1/400
ELISA	1/10000