Description

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

References
1.Breast Cancer Res Treat. 2015 May;151(1):57-73. 2.PLoS One. 2013 Jul 26;8(7):e69851.

Specification
Aliases	MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85
Entrez GeneID	2911
Swissprot	Q13255
clone	5E12D8
WB Predicted band size	132.4kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human GRM1 (AA: extra 387-486) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
ELISA	1/10000