Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

References
1.Pigment Cell Melanoma Res. 2013 May;26(3):348-56. 2.Mol Vis. 2009 Oct 19;15:2094-100.

Specification
Aliases	mGlu6; CSNB1B; GPRC1F; MGLUR6
Entrez GeneID	2916
Swissprot	O15303
clone	4C11E12
WB Predicted band size	95.5kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human GRM6 (AA: extra 480-585) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
ELISA	1/10000