Description

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

References
1.Int J Med Sci. 2020 Oct 18;17(18):2895-2904. 2.Sci Rep. 2020 Oct 13;10(1):17151.

Specification
Aliases	T2D; FJHN; HNF2; LFB3; RCAD; TCF2; HPC11; LF-B3; MODY5; TCF-2; VHNF1; ADTKD3; HNF-1B; HNF1beta; HNF-1-beta
Entrez GeneID	6928
Swissprot	P35680
clone	4H5C7
WB Predicted band size	61.3kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Purified recombinant fragment of human HNF1B (AA: 23-132) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
WB	1/500 - 1/2000
IHC	1/200 - 1/1000
ICC	1/50 - 1/200
FCM	1/200 - 1/400
ELISA	1/10000