Description

CD40 molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

References
1. Clin Cancer Res. 2003 Feb;9(2):722-8. 2. Clin Cancer Res. 2003 Feb;9(2):619-24. 3. Immunity. 1999 Sep;11(3):339-48.

Specification
Aliases	p50; Bp50; CDW40; TNFRSF5
Entrez GeneID	958
Swissprot	P25942
clone	9G10
WB Predicted band size	30.6kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of CD40 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ICC	1/200 - 1/1000
ELISA	1/10000