Description

RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.

References
1. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1198-205. 2. Brain Res Mol Brain Res. 2005 Aug 18;138(2):236-43. 3. FASEB J. 2003 Jul;17(10):1238-47.

Specification
Aliases	HAP; ASYIP; NSPL2; NSPLII; RTN3-A1
Entrez GeneID	10313
Swissprot	O95197
clone	1E11
WB Predicted band size	113kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of RTN3 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ICC	1/200 - 1/1000
ELISA	1/10000