Description

ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

References
1. J Cell Sci. 2005 Jan 15;118(Pt 2):433-46. 2. Oncogene. 1996 Oct 3;13(7):1555-9.

Specification
Aliases	ROR1
Entrez GeneID	4919
Swissprot	Q01973
clone	2H6
WB Predicted band size	101kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ICC	1/200 - 1/1000
ELISA	1/10000