Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

References
1. Biochem Biophys Res Commun. 2008 Dec 19;377(3):852-6. 2. Curr Top Med Chem. 2009;9(3):235-40. 3. Nucleic Acids Res. 2010 May;38(9):2813-24.

Specification
Aliases	HD4; HDACA; HA6116; HDAC-A; KIAA0288; HDAC4
Entrez GeneID	9759
Swissprot	P56524
clone	7B2
WB Predicted band size	119kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human HDAC4 expressed in E. Coli.
Formulation	Purified antibody in PBS containing 0.05% sodium azide.

Application
WB	1/500 - 1/2000
ELISA	1/10000