Description

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References
1. Cell. 2003 Nov 26;115(5):523-35. 2. Cell. 2005 Sep 23;122(6):957-68. 3. Cell. 2006 Nov 3;127(3):635-48.

Specification
Aliases	CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; CBX1
Entrez GeneID	10951
Swissprot	P83916
clone	5A3
WB Predicted band size	21kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Monkey
Immunogen	Purified recombinant fragment of human CBX1 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
ICC	1/200 - 1/1000
FCM	1/200 - 1/400
ELISA	1/10000