Description

Dkk-3 (Dickkopf-3) is a member of the dickkopf family. It is a 350 amino acid secreted glycoprotein that is composed of an N-terminal signal peptide and two conserved cysteine-rich domains, which are separated by a 12 amino acid linker region. This secreted protein is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.

References
1. Virchows Arch. 2009 Jun;454(6):639-46. 2. Gene. 2002 Jan 9;282(1-2):151-8. 3. J Urol. 2004 Mar;171(3):1314-8.

Specification
Aliases	RIG; REIC
Entrez GeneID	27122
Swissprot	Q9UBP4
clone	4G7
WB Predicted band size	38kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Monkey
Immunogen	Purified recombinant fragment of human DKK3 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
FCM	1/200 - 1/400
ELISA	1/10000