Description
Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.

References
1.J Biol Chem. 2000 Oct 27;275(43):33567-73. 2.Mol Cell Biol. 2001 Mar;21(5):1866-73. 3.J Biol Chem. 2003 Jan 24;278(4):2370-6. Epub 2002 Nov 14.

Specification
Aliases	E2A; ITF1; VDIR; bHLHb21; MGC129647; MGC129648; TCF3
Entrez GeneID	6929
Swissprot	P15923
clone	6B8
WB Predicted band size	67.6kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human TCF3 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
FCM	1/200 - 1/400
ELISA	1/10000