Description

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References
1. J Immunol. 2002 Aug 15;169(4):1705-12. 2. Arthritis Rheum. 2003 Jul;48(7):1948-55. 3. Nat Methods. 2005 Aug;2(8):591-8.

Specification
Aliases	T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; CD247
Entrez GeneID	919
Swissprot	P20963
clone	4B10
WB Predicted band size	18kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CD247 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
IHC	1/200 - 1/1000
ICC	1/200 - 1/1000
FCM	1/200 - 1/400
ELISA	1/10000