Description

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in -irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

References
1. Biochem J. 2008 Dec 1;416(2):179-87. 2. Mol Biol Cell. 2008 Nov;19(11):4875-87. 3. Am J Pathol. 2009 Jun;174(6):2107-15.

Specification
Aliases	SLUG; WS2D; SLUGH1; MGC10182; SNAI2
Entrez GeneID	6591
Swissprot	O43623
clone	2H5
WB Predicted band size	30kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ELISA	1/10000