Description

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

References
1. Cytogenet Cell Genet. 1992;61(3):172-4. 2. J Immunol. 1997 Dec 1;159(11):5246-52. 3. J Biol Chem. 2001 Dec 7;276(49):45588-97.

Specification
Aliases	PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
Entrez GeneID	142
Swissprot	P09874
clone	7A10
WB Predicted band size	117kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human PARP, conjugated to KLH.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
FCM	1/200 - 1/400
ELISA	1/10000