Description

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

References
1. Nat Methods. 2005 Aug;2(8):591-8. 2. J Cell Physiol. 2006 Dec;209(3):695-700. Review. 3. J Biol Chem. 2006 Dec 1;281(48):36977-84. Epub 2006 Oct 5.

Specification
Aliases	T3E; TCRE; FLJ18683; CD3E
Entrez GeneID	916
Swissprot	P07766
clone	4E2
WB Predicted band size	23kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of CD3E expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
FCM	1/200 - 1/400
ELISA	1/10000