Description

NTRK3 (neurotrophic tyrosine kinase, receptor, type 3), it is a member of the neurotrophic tyrosine receptor kinase (NTRK) family and plays an important role in the development and maintenance of neural tissues. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

References
1. BMC Cancer. 2007 Oct 31;7:202. 2. J Pathol. 2002 Aug;197(5):661-7.

Specification
Aliases	TRKC; gp145(trkC)
Entrez GeneID	4916
Swissprot	Q16288
clone	4G5
WB Predicted band size	94kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ELISA	1/10000