Description

Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1 or VEGFR-1. It is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

References
1. Mol Med. 2006 Jul-Aug;12(7-8):127-36. 2. Oncogene. 1997 May 29;14(21):2553-61.

Specification
Aliases	FLT; VEGFR1
Entrez GeneID	2321
Swissprot	P17948
clone	3D10
WB Predicted band size	100kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant extracellular fragment of human FLT1 fused with hIgGFc tag expressed in HEK293 cells.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
ELISA	1/10000